Allopurinol as a potential therapeutic agent for recurrent herpes labialis.
Identifieur interne : 002A14 ( Main/Exploration ); précédent : 002A13; suivant : 002A15Allopurinol as a potential therapeutic agent for recurrent herpes labialis.
Auteurs : Mohamed A. El-Farrash [Égypte] ; Jilan M. Youssef ; Shaymaa E. El-MongySource :
- Journal of medical and dental sciences [ 1342-8810 ] ; 2003.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Allopurinol (pharmacologie), Allopurinol (usage thérapeutique), Animaux, Antienzymes (pharmacologie), Antienzymes (usage thérapeutique), Antiviraux (pharmacologie), Antiviraux (usage thérapeutique), Cellules Vero, Femelle, Herpès labial (traitement médicamenteux), Herpèsvirus humain de type 1 (), Humains, Mâle, Prévention secondaire.
- MESH :
- pharmacologie : Allopurinol, Antienzymes, Antiviraux.
- traitement médicamenteux : Herpès labial.
- usage thérapeutique : Allopurinol, Antienzymes, Antiviraux.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Cellules Vero, Femelle, Herpèsvirus humain de type 1, Humains, Mâle, Prévention secondaire.
English descriptors
- KwdEn :
- Adolescent, Adult, Allopurinol (pharmacology), Allopurinol (therapeutic use), Animals, Antiviral Agents (pharmacology), Antiviral Agents (therapeutic use), Chlorocebus aethiops, Enzyme Inhibitors (pharmacology), Enzyme Inhibitors (therapeutic use), Female, Herpes Labialis (drug therapy), Herpesvirus 1, Human (drug effects), Humans, Male, Middle Aged, Secondary Prevention, Vero Cells.
- MESH :
- chemical , pharmacology : Allopurinol, Antiviral Agents, Enzyme Inhibitors.
- chemical , therapeutic use : Allopurinol, Antiviral Agents, Enzyme Inhibitors.
- drug effects : Herpesvirus 1, Human.
- drug therapy : Herpes Labialis.
- Adolescent, Adult, Animals, Chlorocebus aethiops, Female, Humans, Male, Middle Aged, Secondary Prevention, Vero Cells.
Abstract
Recurrent herpes labialis (RHL) occurs in up to 40% of the population. Although the disease is usually self-limiting, patients seek treatment because of the significant pain and visibility of the lesion. Xanthine oxidase inhibitors (XOI) have been reported to have a potent antiviral effect against influenza-A virus. We examined the effect of the systemic xanthine oxidase inhibitor, allopurinol, on RHL duration of illness, severity of symptoms, number and frequency of recurrence during a 4-year follow up period in Egyptian patients. Duration of illness was shortened by about 25%, early disappearance of pain and other symptoms occurred. Also, aborted episodes were noticed when allopurinol was given just after beginning of common colds, at the prodromal stage of RHL or during severe stress conditions. Patients receiving 3 courses of treatment had markedly decreased recurrences during the follow up period. Ex vivo experiments to examine virus-induced plaque formation on Vero cells in the absence or presence of different concentrations of the drug could not prove any direct anti herpetic effect of the drug. However, allopurinol seems to be safe and effective in reducing duration of RHL and to abort lesion or prevent its appearance in treated patients even when they experience immunosuppressive conditions.
PubMed: 12968636
Affiliations:
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El-Farrash</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Microbiology & Immunology, Faculty of Medicine, Mansoura University, Mansoura, Egypt. mfarash@hotmail.com</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Medical Microbiology & Immunology, Faculty of Medicine, Mansoura University, Mansoura</wicri:regionArea><wicri:noRegion>Mansoura</wicri:noRegion></affiliation></author><author><name sortKey="Youssef, Jilan M" sort="Youssef, Jilan M" uniqKey="Youssef J" first="Jilan M" last="Youssef">Jilan M. Youssef</name></author><author><name sortKey="El Mongy, Shaymaa E" sort="El Mongy, Shaymaa E" uniqKey="El Mongy S" first="Shaymaa E" last="El-Mongy">Shaymaa E. El-Mongy</name></author></analytic><series><title level="j">Journal of medical and dental sciences</title><idno type="ISSN">1342-8810</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Allopurinol (pharmacology)</term><term>Allopurinol (therapeutic use)</term><term>Animals</term><term>Antiviral Agents (pharmacology)</term><term>Antiviral Agents (therapeutic use)</term><term>Chlorocebus aethiops</term><term>Enzyme Inhibitors (pharmacology)</term><term>Enzyme Inhibitors (therapeutic use)</term><term>Female</term><term>Herpes Labialis (drug therapy)</term><term>Herpesvirus 1, Human (drug effects)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Secondary Prevention</term><term>Vero Cells</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Allopurinol (pharmacologie)</term><term>Allopurinol (usage thérapeutique)</term><term>Animaux</term><term>Antienzymes (pharmacologie)</term><term>Antienzymes (usage thérapeutique)</term><term>Antiviraux (pharmacologie)</term><term>Antiviraux (usage thérapeutique)</term><term>Cellules Vero</term><term>Femelle</term><term>Herpès labial (traitement médicamenteux)</term><term>Herpèsvirus humain de type 1 ()</term><term>Humains</term><term>Mâle</term><term>Prévention secondaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Allopurinol</term><term>Antiviral Agents</term><term>Enzyme Inhibitors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Allopurinol</term><term>Antiviral Agents</term><term>Enzyme Inhibitors</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Herpesvirus 1, Human</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Herpes Labialis</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Allopurinol</term><term>Antienzymes</term><term>Antiviraux</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Herpès labial</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Allopurinol</term><term>Antienzymes</term><term>Antiviraux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Chlorocebus aethiops</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Secondary Prevention</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Cellules Vero</term><term>Femelle</term><term>Herpèsvirus humain de type 1</term><term>Humains</term><term>Mâle</term><term>Prévention secondaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recurrent herpes labialis (RHL) occurs in up to 40% of the population. Although the disease is usually self-limiting, patients seek treatment because of the significant pain and visibility of the lesion. Xanthine oxidase inhibitors (XOI) have been reported to have a potent antiviral effect against influenza-A virus. We examined the effect of the systemic xanthine oxidase inhibitor, allopurinol, on RHL duration of illness, severity of symptoms, number and frequency of recurrence during a 4-year follow up period in Egyptian patients. Duration of illness was shortened by about 25%, early disappearance of pain and other symptoms occurred. Also, aborted episodes were noticed when allopurinol was given just after beginning of common colds, at the prodromal stage of RHL or during severe stress conditions. Patients receiving 3 courses of treatment had markedly decreased recurrences during the follow up period. Ex vivo experiments to examine virus-induced plaque formation on Vero cells in the absence or presence of different concentrations of the drug could not prove any direct anti herpetic effect of the drug. However, allopurinol seems to be safe and effective in reducing duration of RHL and to abort lesion or prevent its appearance in treated patients even when they experience immunosuppressive conditions.</div></front></TEI><affiliations><list><country><li>Égypte</li></country></list><tree><noCountry><name sortKey="El Mongy, Shaymaa E" sort="El Mongy, Shaymaa E" uniqKey="El Mongy S" first="Shaymaa E" last="El-Mongy">Shaymaa E. El-Mongy</name><name sortKey="Youssef, Jilan M" sort="Youssef, Jilan M" uniqKey="Youssef J" first="Jilan M" last="Youssef">Jilan M. Youssef</name></noCountry><country name="Égypte"><noRegion><name sortKey="El Farrash, Mohamed A" sort="El Farrash, Mohamed A" uniqKey="El Farrash M" first="Mohamed A" last="El-Farrash">Mohamed A. 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